Fort Myers is a city in and the county seat of Lee County, Florida, United States. The Census Bureau's Population Estimates Program calculated that the city's population was 92,245 in 2021, ranking the city the 370th-most-populous in the country. Together with the larger and more residential city of Cape Coral, the smaller cities of Fort Myers Beach, Sanibel, and Bonita Springs, the village of Estero, and the unincorporated districts of Lehigh Acres and North Fort Myers, it anchors a metropolitan statistical area (MSA) which comprises Lee County and has a population of 787,976 as of 2021.

Fort Myers is a gateway to the Southwest Florida region and a major tourist destination within Florida. The winter estates of Thomas Edison "Seminole Lodge" and Henry Ford "The Mangoes" are major attractions. The city takes its name from a local former fort that was built during the Seminole Wars.The fort in turn took its name from Colonel Abraham Myers in 1850; Myers served in the United States Army, mostly the Quartermaster Department, in various posts from 1833 to 1861 and was the quartermaster general of the Confederate States Army from 1861 to 1864.